Understanding Ion Channel Biology in the Kidney and Beyond
Investigating a New Pathway for Misfolded Protein Quality Control and Degradation
Dissecting Lipotoxicity Pathways and their Effect on Proteostasis
Harnessing Next-Generation Tools to Gain Insights at Single-Cell Resolution
A major focus of the lab is the role of the TMED family of cargo receptors in protein quality control, trafficking, and secretion. A recent study from our lab revealed that TMEDs handle several misfolded membrane and secretory protein cargoes including mucin 1, uromodulin and rhodopsin. This work has implications for toxic proteinopathies affecting the kidney, the eye, the brain and beyond.
Another area of active investigation is the intersection of lipotoxicity and proteostasis across the lifespan. Taking advantage of a systematic approach to study cell states after exposure to specific lipid species, this work may ultimately uncover molecular targets that reflect the convergence of genetic and environmental risk for a host of human metabolic and degenerative diseases.
The lab is harnessing the power of scalable approaches such as spatial and single cell technologies, proteomics and functional genomics to deeply characterize cells and tissues in health and disease.